Mechanism of resistance of human immunodeficiency virus type 1 to 2',3'-dideoxyinosine.

A molecular clone containing the wild-type reverse transcriptase (RT) coding region of human immunodeficiency virus type 1 (HIV-1) was constructed, and site-directed mutagenesis was used to introduce mutations--Leu74-->Val (L74V), T215Y, and the combination L74V/T215Y--into the RT coding region....

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Autores principales: Martin, J L, Wilson, J E, Haynes, R L, Furman, P A
Formato: Artigo
Lenguaje:Inglês
Publicado: 1993
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC46882/
https://ncbi.nlm.nih.gov/pubmed/7687061
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