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Isotope-encoded Carboxyl Group Footprinting for Mass Spectrometry-based Protein Conformational Studies

We report an isotope-encoding method coupled with carboxyl-group footprinting to monitor protein conformational changes. The carboxyl groups of aspartic/glutamic acids and of the C-terminus of proteins can serve as reporters for protein conformational changes when labeled with glycine ethyl ester (G...

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Bibliografiske detaljer
Udgivet i:J Am Soc Mass Spectrom
Main Authors: Zhang, Hao, Liu, Haijun, Blankenship, Robert E., Gross, Michael L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688080/
https://ncbi.nlm.nih.gov/pubmed/26384685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-015-1260-5
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