Packed Bed Bioreactor for the Isolation and Expansion of Placental-Derived Mesenchymal Stromal Cells

Large numbers of Mesenchymal stem/stromal cells (MSCs) are required for clinical relevant doses to treat a number of diseases. To economically manufacture these MSCs, an automated bioreactor system will be required. Herein we describe the development of a scalable closed-system, packed bed bioreacto...

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Bibliographic Details
Published in:PLoS One
Main Authors: Osiecki, Michael J., Michl, Thomas D., Kul Babur, Betul, Kabiri, Mahboubeh, Atkinson, Kerry, Lott, William B., Griesser, Hans J., Doran, Michael R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687640/
https://ncbi.nlm.nih.gov/pubmed/26660475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144941
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