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7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium.

Previous studies have shown that the immunosuppressive and carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) impairs Ca(2+)-dependent transmembrane signaling in human and murine lymphocytes. The purpose of the present studies was to analyze potential mechanisms of im...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Archuleta, M M, Schieven, G L, Ledbetter, J A, Deanin, G G, Burchiel, S W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46876/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8327490/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.13.6105
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