Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination

Protein Numb, first identified as a cell-fate determinant in Drosophila, has been shown to promote the development of neurites in mammals and to be cotransported with endocytic receptors in clathrin-coated vesicles in vitro. Nevertheless, its function in mature neurons has not yet been elucidated. H...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Zhou, Liang, Yang, Dong, Wang, De-Juan, Xie, Ya-Jun, Zhou, Jia-Huan, Zhou, Lin, Huang, Hao, Han, Shuo, Shao, Chong-Yu, Li, Hua-Shun, Zhu, J. Julius, Qiu, Meng-Sheng, De Zeeuw, Chris I., Shen, Ying
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687583/
https://ncbi.nlm.nih.gov/pubmed/26621723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512915112
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