Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma

BACKGROUND: Abnormal activation of STAT3 and miR-21 plays a vital role in progression and invasion of solid tumors. The cyclin-dependent kinase 5 (CDK5) is reported to contribute to cancer metastasis by regulating epithelial-mesenchymal transition (EMT). However, the role of STAT3/miR-21 axis and CD...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Sun, Shan-Shan, Zhou, Xuan, Huang, Yuan-Yuan, Kong, Ling-Ping, Mei, Mei, Guo, Wen-Yu, Zhao, Ming-Hui, Ren, Yu, Shen, Qiang, Zhang, Lun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687320/
https://ncbi.nlm.nih.gov/pubmed/26690371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0487-x
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