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An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility
The voltage-gated Kv1.3 K(+) channel plays a key role in the activation of T lymphocytes. Kv1.3 blockers selectively suppress immune responses mediated by effector memory T cells, which indicates the great potential of selective Kv1.3 inhibitors in the therapy of certain autoimmune diseases. Anuroct...
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| Izdano u: | Sci Rep |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4686915/ https://ncbi.nlm.nih.gov/pubmed/26689143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18397 |
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