Cold-aggravated pain in humans caused by a hyperactive Na(V)1.9 channel mutant

Gain-of-function mutations in the human SCN11A-encoded voltage-gated Na(+) channel Na(V)1.9 cause severe pain disorders ranging from neuropathic pain to congenital pain insensitivity. However, the entire spectrum of the Na(V)1.9 diseases has yet to be defined. Applying whole-exome sequencing we here...

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Pubblicato in:Nat Commun
Autori principali: Leipold, Enrico, Hanson-Kahn, Andrea, Frick, Miya, Gong, Ping, Bernstein, Jonathan A., Voigt, Martin, Katona, Istvan, Oliver Goral, R., Altmüller, Janine, Nürnberg, Peter, Weis, Joachim, Hübner, Christian A., Heinemann, Stefan H., Kurth, Ingo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686659/
https://ncbi.nlm.nih.gov/pubmed/26645915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10049
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