Identification of the Novel TMEM16A Inhibitor Dehydroandrographolide and Its Anticancer Activity on SW620 Cells

TMEM16A, a calcium-activated chloride channel (CaCC), is highly amplified and expressed in human cancers and is involved in the growth and metastasis of some malignancies. Inhibition of TMEM16A represents a novel pharmaceutical approach for the treatment of cancers and metastases. The purpose of thi...

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Udgivet i:PLoS One
Main Authors: Sui, Yujie, Wu, Fei, Lv, Junfeng, Li, Hongxia, Li, Xin, Du, Zhenwu, Sun, Meiyan, Zheng, Yuhao, Yang, Longfei, Zhong, Lili, Zhang, Xingyi, Zhang, Guizhen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686118/
https://ncbi.nlm.nih.gov/pubmed/26657333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144715
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