Role of TLR4-Mediated PI3K/AKT/GSK-3β Signaling Pathway in Apoptosis of Rat Hepatocytes

We investigated the mechanism of the Toll-like receptor 4- (TLR4-) mediated PI3K/AKT/GSK-3β signaling pathway in rat hepatocytes apoptosis induced by LPS. The cultured rat hepatocytes were treated with LPS alone or first pretreated with TLR4 inhibitor, AKT inhibitor, and GSK-3β inhibitor, respective...

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Publicat a:Biomed Res Int
Autors principals: Zhang, Xian, Jiang, Daorong, Jiang, Wei, Zhao, Min, Gan, Jianhe
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685073/
https://ncbi.nlm.nih.gov/pubmed/26770978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/631326
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