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The DNA ligase IV syndrome R278H mutation impairs B-lymphopoiesis via error-prone non-homologous end-joining()
Hypomorphic mutations in the non-homologous end-joining (NHEJ) DNA repair protein DNA Ligase IV (LIG4) lead to immunodeficiency with varying severity. Here, using a murine knock-in model, we investigated the mechanisms underlying abnormalities in class switch recombination (CSR) associated with the...
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| Udgivet i: | J Immunol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4684978/ https://ncbi.nlm.nih.gov/pubmed/26608917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1403099 |
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