STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation

Lung fibrosis is the hallmark of the interstitial lung diseases. Alveolar epithelial cell (AEC) injury is a key step that contributes to a profibrotic microenvironment. Fibroblasts and myofibroblasts subsequently accumulate and deposit excessive extracellular matrix. In addition to TGF-β, the IL-6 f...

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Vydáno v:FASEB J
Hlavní autoři: Pedroza, Mesias, Le, Thuy T., Lewis, Katherine, Karmouty-Quintana, Harry, To, Sarah, George, Anuh T., Blackburn, Michael R., Tweardy, David J., Agarwal, Sandeep K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2016
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684532/
https://ncbi.nlm.nih.gov/pubmed/26324850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-273953
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