An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells

Leukemia differs substantially with respect to stromal milieu from tumors that progress locally as solid masses, and the physiological importance of immunosurveillance in leukemia remains unclear. However, currently available mouse leukemia models have critical limitations in the context of analyzin...

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Veröffentlicht in:PLoS One
Hauptverfasser: Hasegawa, Kana, Tanaka, Satomi, Fujiki, Fumihiro, Morimoto, Soyoko, Nakajima, Hiroko, Tatsumi, Naoya, Nakata, Jun, Takashima, Satoshi, Nishida, Sumiyuki, Tsuboi, Akihiro, Oka, Yoshihiro, Oji, Yusuke, Kumanogoh, Atsushi, Sugiyama, Haruo, Hosen, Naoki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684241/
https://ncbi.nlm.nih.gov/pubmed/26658107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144594
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