Kinetic response of wild and mutant core codon 70 strains of HCV genotype 1b to pegylated interferon-α and ribavirin therapy

BACKGROUND: Amino acid (aa) 70 substitution (R70Q/H) in the core protein of hepatitis C virus (HCV) genotype 1b has been shown to be one of the key factors in determining resistance for pegylated interferon-α plus ribavirin combination therapy (PEG-IFNα/RBV). But the exact mechanisms remain unclear....

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Dettagli Bibliografici
Pubblicato in:Virol J
Autori principali: Hu, Zhongjie, Liu, Ying, Qiu, Lixia, Fan, Zuopeng, Nie, Wei, Liang, Shan, Jin, Ronghua
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683707/
https://ncbi.nlm.nih.gov/pubmed/26684004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-015-0451-9
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