Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

We developed a new statistical framework to find genetic variants associated with extreme longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large studies of age-related disease in order to narrow the search for SNPs associated with longevity. To gain support for our app...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Fortney, Kristen, Dobriban, Edgar, Garagnani, Paolo, Pirazzini, Chiara, Monti, Daniela, Mari, Daniela, Atzmon, Gil, Barzilai, Nir, Franceschi, Claudio, Owen, Art B., Kim, Stuart K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683064/
https://ncbi.nlm.nih.gov/pubmed/26677855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005728
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