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Cys34-PEGylated Human Serum Albumin for Drug Binding and Delivery

Polyethylene glycol (PEG) derivatives were conjugated onto the Cys-34 residue of human serum albumin (HSA) to determine their effects on the solubilization, permeation, and cytotoxic activity of hydrophobic drugs such as paclitaxel (PTX). PEG(C34)HSA conjugates were prepared on a multigram scale by...

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Pubblicato in:Bioconjug Chem
Autori principali: Mehtala, Jonathan G., Kulczar, Chris, Lavan, Monika, Knipp, Gregory, Wei, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683017/
https://ncbi.nlm.nih.gov/pubmed/25918947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00143
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