Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans

A spiroindolinone (1S,3R,3aR,6aS)-1-benzyl-6′-chloro-5-(4-fluorophenyl)-7′-methylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3′-1H-indole]-2′,4,6-trione was previously reported to enhance the antifungal effect of fluconazole against C. albicans. A diastereomer of that compound was synthesized,...

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Publicado en:ChemMedChem
Main Authors: Premachandra, Ilandari Dewage Udara Anulal, Scott, Kevin A., Shen, Chengtian, Wang, Fuqiang, Lane, Shelley, Liu, Haoping, Van Vranken, David L.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682886/
https://ncbi.nlm.nih.gov/pubmed/26263912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500271
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