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Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF-Hands

Recoverin (Rv), a small Ca(2+)-binding protein that inhibits rhodopsin kinase (RK), has four EF hands, two of which are functional (EF2 and EF3). Activation requires Ca(2+) in both EF hands, but crystal structures have never been observed with Ca(2+) ions in both sites; all previous structures have...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Kumar, Ramasamy P., Ranaghan, Matthew J., Ganjei, Allen Y., Oprian, Daniel D.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682395/
https://ncbi.nlm.nih.gov/pubmed/26584024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01160
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