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Notch-Dependent Pituitary SOX2(+) Stem Cells Exhibit a Timed Functional Extinction in Regulation of the Postnatal Gland

Although SOX2(+) stem cells are present in the postnatal pituitary gland, how they are regulated molecularly and whether they are required for pituitary functions remain unresolved questions. Using a conditional knockout animal model, here we demonstrate that ablation of the canonical Notch signalin...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Zhu, Xiaoyan, Tollkuhn, Jessica, Taylor, Havilah, Rosenfeld, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682291/
https://ncbi.nlm.nih.gov/pubmed/26651607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.11.001
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