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Anxiolytic- and Antidepressant-like Effects of the Methadone Metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP)

The enhancement of GABAergic and monoaminergic neurotransmission has been the mainstay of pharmacotherapy and the focus of drug-discovery for anxiety and depressive disorders for several decades. However, the significant limitations of drugs used for these disorders underscores the need for novel th...

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Publicado no:Neuropharmacology
Main Authors: Forcelli, Patrick A., Turner, Jill R., Lee, Bridgin G., Olson, Thao T., Xie, Teresa, Xiao, Yingxian, Blendy, Julie A., Kellar, Kenneth J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681651/
https://ncbi.nlm.nih.gov/pubmed/26365569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.09.012
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