Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade

Hapalindoles are bioactive indole alkaloids with fascinating polycyclic ring systems whose biosynthetic assembly mechanism has remained unknown since their initial discovery in the 1980s. In this study, we describe the fam gene cluster from the cyanobacterium Fischerella ambigua UTEX 1903 encoding h...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Li, Shasha, Lowell, Andrew N., Yu, Fengan, Raveh, Avi, Newmister, Sean A., Bair, Nathan, Schaub, Jeffrey M., Williams, Robert M., Sherman, David H.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681624/
https://ncbi.nlm.nih.gov/pubmed/26629885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b10136
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