Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade

Hapalindoles are bioactive indole alkaloids with fascinating polycyclic ring systems whose biosynthetic assembly mechanism has remained unknown since their initial discovery in the 1980s. In this study, we describe the fam gene cluster from the cyanobacterium Fischerella ambigua UTEX 1903 encoding h...

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Détails bibliographiques
Publié dans:J Am Chem Soc
Auteurs principaux: Li, Shasha, Lowell, Andrew N., Yu, Fengan, Raveh, Avi, Newmister, Sean A., Bair, Nathan, Schaub, Jeffrey M., Williams, Robert M., Sherman, David H.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681624/
https://ncbi.nlm.nih.gov/pubmed/26629885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b10136
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