Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade

Hapalindoles are bioactive indole alkaloids with fascinating polycyclic ring systems whose biosynthetic assembly mechanism has remained unknown since their initial discovery in the 1980s. In this study, we describe the fam gene cluster from the cyanobacterium Fischerella ambigua UTEX 1903 encoding h...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Li, Shasha, Lowell, Andrew N., Yu, Fengan, Raveh, Avi, Newmister, Sean A., Bair, Nathan, Schaub, Jeffrey M., Williams, Robert M., Sherman, David H.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681624/
https://ncbi.nlm.nih.gov/pubmed/26629885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b10136
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