Dopamine D(2/3) Receptor Occupancy Following Dose Reduction Is Predictable With Minimal Plasma Antipsychotic Concentrations: An Open-Label Clinical Trial

BACKGROUND. Population pharmacokinetics can predict antipsychotic blood concentrations at a given time point prior to a dosage change. Those predicted blood concentrations could be used to estimate the corresponding dopamine D(2/3) receptors (D(2/3)R) occupancy by antipsychotics based on the tight r...

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Detalles Bibliográficos
Publicado en:Schizophr Bull
Main Authors: Nakajima, Shinichiro, Uchida, Hiroyuki, Bies, Robert R., Caravaggio, Fernando, Suzuki, Takefumi, Plitman, Eric, Mar, Wanna, Gerretsen, Philip, Pollock, Bruce G., Mulsant, Benoit H., Mamo, David C., Graff-Guerrero, Ariel
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681559/
https://ncbi.nlm.nih.gov/pubmed/26221049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbv106
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