Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes

BACKGROUND: Rhabdoid tumors (RTs) are aggressive tumors of early childhood that occur most often in brain (AT/RTs) or kidney (KRTs). Regardless of location, they are characterized by loss of functional SMARCB1 protein, a component of the SWI/SNF chromatin remodeling complex. The aim of this study wa...

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Publicado no:Pediatr Blood Cancer
Main Authors: Birks, Diane K, Donson, Andrew M., Patel, Purvi R., Sufit, Alexandra, Algar, Elizabeth M., Dunham, Christopher, Kleinschmidt-DeMasters, B. K., Handler, Michael H., Vibhakar, Rajeev, Foreman, Nicholas K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681512/
https://ncbi.nlm.nih.gov/pubmed/23382118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24481
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