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Close and allosteric opening of the polypeptide-binding site in a human Hsp70 chaperone BiP
BiP, an essential and ubiquitous Hsp70 chaperone in the endoplasmic reticulum, plays a key role in protein folding and quality control. BiP contains two functional domains: a nucleotide binding domain (NBD) and a substrate-binding domain (SBD). NBD binds and hydrolyzes ATP; the substrates for SBD ar...
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| Pubblicato in: | Structure |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4680848/ https://ncbi.nlm.nih.gov/pubmed/26655470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.10.012 |
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