Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

The 11;22 chromosomal translocation specifically linked to Ewing sarcoma and primitive neuroectodermal tumor results in a chimeric molecule fusing the amino-terminal-encoding portion of the EWS gene to the carboxyl-terminal DNA-binding domain encoded by the FLI1 gene. We have isolated a fourth EWS-F...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	May, W A, Gishizky, M L, Lessnick, S L, Lunsford, L B, Lewis, B C, Delattre, O, Zucman, J, Thomas, G, Denny, C T
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1993
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46800/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8516324/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.12.5752
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