Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study

INTRODUCTION: Type 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing β cells in the pancreatic islets, leading to insulinopenia and hyperglycaemia. Genetic analyses indicate that alterations of the interleukin-2 (IL-2) pathway mediating immune activation and tolerance pre...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Truman, Lucy A, Pekalski, Marcin L, Kareclas, Paula, Evangelou, Marina, Walker, Neil M, Howlett, James, Mander, Adrian P, Kennet, Jane, Wicker, Linda S, Bond, Simon, Todd, John A, Waldron-Lynch, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2015
Assuntos:
Diabetes and Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679899/
https://ncbi.nlm.nih.gov/pubmed/26646829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2015-009799
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