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Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine
Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs. We report here that the activities of two Dnmt2 homologs, Pmt1 from Schizosaccharomyces pombe and DnmA from Dictyostelium discoideum, are strongly stimulated by prior queuosine (Q) modification of the substrate tRNA...
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| Опубликовано в: : | Nucleic Acids Res |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4678861/ https://ncbi.nlm.nih.gov/pubmed/26424849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv980 |
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