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Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine
Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs. We report here that the activities of two Dnmt2 homologs, Pmt1 from Schizosaccharomyces pombe and DnmA from Dictyostelium discoideum, are strongly stimulated by prior queuosine (Q) modification of the substrate tRNA...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4678861/ https://ncbi.nlm.nih.gov/pubmed/26424849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv980 |
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