Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine

Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs. We report here that the activities of two Dnmt2 homologs, Pmt1 from Schizosaccharomyces pombe and DnmA from Dictyostelium discoideum, are strongly stimulated by prior queuosine (Q) modification of the substrate tRNA...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Müller, Martin, Hartmann, Mark, Schuster, Isabelle, Bender, Sebastian, Thüring, Kathrin L., Helm, Mark, Katze, Jon R., Nellen, Wolfgang, Lyko, Frank, Ehrenhofer-Murray, Ann E.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678861/
https://ncbi.nlm.nih.gov/pubmed/26424849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv980
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