Ester-Mediated Amide Bond Formation Driven by Wet–Dry Cycles: A Possible Path to Polypeptides on the Prebiotic Earth**

Although it is generally accepted that amino acids were present on the prebiotic Earth, the mechanism by which α-amino acids were condensed into polypeptides before the emergence of enzymes remains unsolved. Here, we demonstrate a prebiotically plausible mechanism for peptide (amide) bond formation...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Forsythe, Jay G, Yu, Sheng-Sheng, Mamajanov, Irena, Grover, Martha A, Krishnamurthy, Ramanarayanan, Fernández, Facundo M, Hud, Nicholas V
Format: Artigo
Sprog:Inglês
Udgivet: WILEY-VCH Verlag 2015
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678426/
https://ncbi.nlm.nih.gov/pubmed/26201989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201503792
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