Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study

PURPOSE: The best screening practice for Lynch syndrome (LS) in endometrial cancer (EC) remains unknown. We sought to determine whether tumor microsatellite instability (MSI) typing along with immunohistochemistry (IHC) and MLH1 methylation analysis can help identify women with LS. PATIENTS AND METH...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Goodfellow, Paul J., Billingsley, Caroline C., Lankes, Heather A., Ali, Shamshad, Cohn, David E., Broaddus, Russell J., Ramirez, Nilsa, Pritchard, Colin C., Hampel, Heather, Chassen, Alexis S., Simmons, Luke V., Schmidt, Amy P., Gao, Feng, Brinton, Louise A., Backes, Floor, Landrum, Lisa M., Geller, Melissa A., DiSilvestro, Paul A., Pearl, Michael L., Lele, Shashikant B., Powell, Matthew A., Zaino, Richard J., Mutch, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678181/
https://ncbi.nlm.nih.gov/pubmed/26552419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.63.9518
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