A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates

There is a medical need for safe and efficacious anti-obesity drugs with acceptable side effect profiles. To mitigate the challenge posed by translating target interaction across species and balancing beneficial vs. adverse effects, a positron emission tomography (PET) approach could help guide clin...

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Udgivet i:Neuropharmacology
Main Authors: Hjorth, Stephan, Karlsson, Cecilia, Jucaite, Aurelija, Varnäs, Katarina, Hamrén, Ulrika Wählby, Johnström, Peter, Gulyás, Balázs, Donohue, Sean R, Pike, Victor W, Halldin, Christer, Farde, Lars
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678037/
https://ncbi.nlm.nih.gov/pubmed/25791528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.03.002
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