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A Stable Bidentate Protein Binder Achieved via DNA Self-Assembly Driven Ligand Migration
Herein we disclose the development of two complementary single stranded DNA-small molecule chimeras (DCs) that by themselves only bind weakly to a protein target (human serum albumin; HSA). However, upon self-assembly, the DC duplex facilitates a ligand migration reaction leading to a covalently fas...
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| Publicado no: | Chem Commun (Camb) |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4677574/ https://ncbi.nlm.nih.gov/pubmed/26225890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc03213j |
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