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Nucleic Acid Targeted Therapy: G4 Oligonucleotides Downregulate HRAS in Bladder Cancer Cells through a Decoy Mechanism
[Image: see text] In a previous study we have demonstrated that two neighboring G-quadruplexes, hras-1 and hras-2, located immediately upstream of the major transcription start site of HRAS, bind MAZ, a nuclear factor that activates transcription (Cogoi, S.; et al. Nucl. Acid Res.2014, 42, 8379). Fo...
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| Veröffentlicht in: | ACS Med Chem Lett |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2015
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4677363/ https://ncbi.nlm.nih.gov/pubmed/26713101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00315 |
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