A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

Bispecific antibodies, while showing great therapeutic potential, pose formidable challenges with respect to their assembly, stability, immunogenicity, and pharmacodynamics. Here we describe a novel class of bispecific antibodies with native human immunoglobulin format. The design exploits differenc...

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Publicado no:Sci Rep
Main Authors: Smith, Eric J., Olson, Kara, Haber, Lauric J., Varghese, Bindu, Duramad, Paurene, Tustian, Andrew D., Oyejide, Adelekan, Kirshner, Jessica R., Canova, Lauren, Menon, Jayanthi, Principio, Jennifer, MacDonald, Douglas, Kantrowitz, Joel, Papadopoulos, Nicholas, Stahl, Neil, Yancopoulos, George D., Thurston, Gavin, Davis, Samuel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675964/
https://ncbi.nlm.nih.gov/pubmed/26659273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17943
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