Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer

AIM: To investigate the mechanism of action of lipophilic antidepressant fluoxetine (FLX) in representative molecular subtypes of breast cancer. METHODS: The anti-proliferative effects and mechanistic action of FLX in triple-negative (SUM149PT) and luminal (T47D and Au565) cancer cells and non-trans...

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Bibliographische Detailangaben
Veröffentlicht in:World J Clin Oncol
Hauptverfasser: Bowie, Michelle, Pilie, Patrick, Wulfkuhle, Julia, Lem, Siya, Hoffman, Abigail, Desai, Shraddha, Petricoin, Emanuel, Carter, Amira, Ambrose, Adrian, Seewaldt, Victoria, Yu, Dihua, Ibarra Drendall, Catherine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Baishideng Publishing Group Inc 2015
Schlagworte:
Basic Study
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675916/
https://ncbi.nlm.nih.gov/pubmed/26677444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5306/wjco.v6.i6.299
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