Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures

Protamines confer a compact structure to the genome of male gametes. Here, we find that somatic cells can be remodeled by transient expression of protamine 1 (Prm1). Ectopically expressed Prm1 forms scattered foci in the nuclei of fibroblasts, which coalescence into spermatid-like structures, concom...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Iuso, Domenico, Czernik, Marta, Toschi, Paola, Fidanza, Antonella, Zacchini, Federica, Feil, Robert, Curtet, Sandrine, Buchou, Thierry, Shiota, Hitoshi, Khochbin, Saadi, Ptak, Grazyna Ewa, Loi, Pasqualino
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675893/
https://ncbi.nlm.nih.gov/pubmed/26628361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.066
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