Developmental Activation of the AHR Increases Effector CD4(+) T Cells and Exacerbates Symptoms in Autoimmune Disease-Prone Gnaq(+/)(−) Mice

Perinatal environmental exposures are potentially important contributors to the increase in autoimmune diseases. Yet, the mechanisms by which these exposures increase self-reactive immune responses later in life are poorly understood. Autoimmune diseases require CD4(+) T cells for initiation, progre...

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Foilsithe in:Toxicol Sci
Main Authors: Boule, Lisbeth A., Burke, Catherine G., Fenton, Bruce M., Thevenet-Morrison, Kelly, Jusko, Todd A., Lawrence, B. Paige
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2015
Ábhair:
Aryl Hydrocarbon Receptor Activation and Autoimmunity
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675837/
https://ncbi.nlm.nih.gov/pubmed/26363170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv203
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