Small molecules efficiently reprogram human astroglial cells into functional neurons

We have recently demonstrated that reactive glial cells can be directly reprogrammed into functional neurons by single neural transcription factor NeuroD1. Here we report that a combination of small molecules can also reprogram human astrocytes in culture into fully functional neurons. We demonstrat...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Zhang, Lei, Yin, Jiu-Chao, Yeh, Hana, Ma, Ning-Xin, Lee, Grace, Chen, Xiangyun Amy, Wang, Yanming, Lin, Li, Chen, Li, Jin, Peng, Wu, Gang-Yi, Chen, Gong
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675726/
https://ncbi.nlm.nih.gov/pubmed/26481520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.09.012
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