Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells

Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense system in the human lung. In this study, we demon...

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Dettagli Bibliografici
Pubblicato in:PeerJ
Autori principali: Karadottir, Harpa, Kulkarni, Nikhil Nitin, Gudjonsson, Thorarinn, Karason, Sigurbergur, Gudmundsson, Gudmundur Hrafn
Natura: Artigo
Lingua:Inglês
Pubblicazione: PeerJ Inc. 2015
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675098/
https://ncbi.nlm.nih.gov/pubmed/26664810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.1483
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