Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes

The progressive mechanism underlying myelodysplastic syndrome remains unknown. Here we identify ROBO1 and ROBO2 as novel progression-related somatic mutations using whole-exome and targeted sequencing in 6 of 16 (37.5%) paired MDS patients with disease progression. Further deep sequencing detects 20...

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Publicat a:Nat Commun
Autors principals: Xu, Feng, Wu, Ling-Yun, Chang, Chun-Kang, He, Qi, Zhang, Zheng, Liu, Li, Shi, Wen-Hui, Guo, Juan, Zhu, Yang, Zhao, You-Shan, Gu, Shu-Cheng, Fei, Cheng-Ming, Wu, Dong, Zhou, Li-Yu, Su, Ji-Ying, Song, Lu-Xi, Xiao, Chao, Li, Xiao
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674765/
https://ncbi.nlm.nih.gov/pubmed/26608094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9806
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