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Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells

AIM: To determine the therapeutic potential of sphingosine kinase 1 (Sphk1) inhibition and its underlying mechanism in a well-characterized mouse model of D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced acute liver failure (ALF). METHODS: Balb/c mice were randomly assigned to different gro...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Lei, Yan-Chang, Yang, Ling-Ling, Li, Wen, Luo, Pan, Zheng, Pei-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674723/
https://ncbi.nlm.nih.gov/pubmed/26676341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i46.13055
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