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CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing
Cytochrome P450 3A4 (CYP3A4) metabolizes 30–50% of clinically used drugs. Large interperson variability in CYP3A4 activity affects response to CYP3A4 substrate drugs. We had demonstrated that an intronic single nucleotide polymorphism (SNP) rs35599367 (CYP3A4*22, located in intron 6) reduces mRNA/pr...
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| Pubblicato in: | Pharmacogenet Genomics |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4674354/ https://ncbi.nlm.nih.gov/pubmed/26488616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000183 |
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