Genetic Targeting of Protease Activated Receptor 2 Reduces Inflammatory Astrogliosis and Improves Recovery of Function after Spinal Cord Injury

Inflammatory-astrogliosis exacerbates damage in the injured spinal cord and limits repair. Here we identify Protease Activated Receptor 2 (PAR2) as an essential regulator of these events with mice lacking the PAR2 gene showing greater improvements in motor coordination and strength after compression...

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Publicado en:Neurobiol Dis
Autores principales: Radulovic, Maja, Yoon, Hyesook, Wu, Jianmin, Mustafa, Karim, Fehlings, Michael G., Scarisbrick, Isobel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674329/
https://ncbi.nlm.nih.gov/pubmed/26316358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.08.021
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