Conserved Regulation of the JAK/STAT Pathway by the Endosomal Protein Asrij Maintains Stem Cell Potency

Asrij/OCIAD1 is an endosomal protein expressed in stem cells and cardiovascular lineages and aberrantly expressed in several cancers. We show that dose-dependent modulation of cytokine-dependent JAK/STAT signaling by Asrij regulates mouse embryonic stem cell pluripotency as well as Drosophila hemato...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Sinha, Abhishek, Khadilkar, Rohan J., Vinay, K. S., Sinha, Arghyashree RoyChowdhury, Inamdar, Maneesha S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673900/
https://ncbi.nlm.nih.gov/pubmed/23972987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.029
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