Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke

Cyclooxygenase-2 (COX-2) is activated in response to ischemia and significantly contributes to the neuroinflammatory process. Accumulation of COX-2-derived prostaglandin E(2) (PGE(2)) parallels the substantial increase in stroke-mediated blood-brain barrier (BBB) breakdown. Disruption of the BBB is...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Frankowski, Jan C., DeMars, Kelly M., Ahmad, Abdullah S., Hawkins, Kimberly E., Yang, Changjun, Leclerc, Jenna L., Doré, Sylvain, Candelario-Jalil, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673693/
https://ncbi.nlm.nih.gov/pubmed/26648273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17956
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