The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells

Glioma cells release glutamate through expression of system x(c)(−), which exchanges intracellular glutamate for extracellular cysteine. Lack of the excitatory amino acid transporter 2 (EAAT2) expression maintains high extracellular glutamate levels in the glioma microenvironment, causing excitotoxi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ching, Jared, Amiridis, Stephanie, Stylli, Stanley S., Bjorksten, Andrew R., Kountouri, Nicole, Zheng, Thomas, Paradiso, Lucy, Luwor, Rodney B., Morokoff, Andrew P., O'Brien, Terence J., Kaye, Andrew H.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673266/
https://ncbi.nlm.nih.gov/pubmed/26046374
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