Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3

Protein arginine methyltransferases (PRMTs) plays critical roles in cancer. PRMT5 has been implicated in several types of tumors. However, the role of PRMT5 in cancer development remains to be fully elucidated. Here, we provide evidence that PRMT5 is overexpressed in colorectal cancer (CRC) cells an...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Baolai, Dong, Shuhong, Zhu, Ruiming, Hu, Chunyan, Hou, Jing, Li, Yan, Zhao, Qian, Shao, Xue, Bu, Qian, Li, Hongyu, Wu, Yongjie, Cen, Xiaobo, Zhao, Yinglan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673200/
https://ncbi.nlm.nih.gov/pubmed/26078354
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