Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents

The capacity of tumor cells for nucleotide excision repair (NER) is a major determinant of the efficacy of and resistance to DNA-damaging chemotherapeutics, such as cisplatin. Here, we demonstrate that using lesion-specific monoclonal antibodies, NER capacity is enhanced in human lung cancer cells a...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Choi, Ji Ye, Park, Jeong-Min, Yi, Joo Mi, Leem, Sun-Hee, Kang, Tae-Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673183/
https://ncbi.nlm.nih.gov/pubmed/26317794
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