CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells

NANOG expression in prostate cancer is highly correlated with cancer stem cell characteristics and resistance to androgen deprivation. However, it is not clear whether NANOG or its pseudogenes contribute to the malignant potential of cancer. We established NANOG- and NANOGP8-knockout DU145 prostate...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Kawamura, Norihiko, Nimura, Keisuke, Nagano, Hiromichi, Yamaguchi, Sohei, Nonomura, Norio, Kaneda, Yasufumi
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673169/
https://ncbi.nlm.nih.gov/pubmed/26087476
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